Resveratrol accelerates wound healing by attenuating oxidative stress-induced impairment of cell proliferation and migration

Abstract Background Impaired wound healing, which is due to various external and internal factors that are involved in wound pathophysiology, leads to high rates of morbidity and mortality worldwide. Oxidative stress injury is an important factor that affects wound healing by changing the whole healing process. So, resveratrol, a dietary fruits polyphenol, which is known for its antioxidant properties, maybe the candidate to accelerate the wound-healing process. Methods The Human Umbilical Vein Endothelial Cells (HUVECs) was used for in vitro experiments to evaluate the effect of resveratrol on hyperglycemia-induced gene expression, oxidative stress and cell proliferation. The diabetic rat model was used to evaluate the effect of resveratrol on cutaneous burn injury healing process. Results Increases in H2O2 decreased cell viability with the 0-800 μM concentration range, and resveratrol could protect HUVECs against H2O2-induced injury. The scratched wound closed rate in H2O2 group was significantly smaller than the Control group (p  Conclusions Resveratrol has the positive effects on promoting the acceleration and quality of skin wound healing, which maybe at least in part caused by the up-regulation of nuclear Nrf2 and Mn-SOD that subsequently attenuated oxidative stress.