Clinical research of esomeprazole quadraple therapy in the treatment of intractable peptic ulcer

Objective To study the curative effects of quadruple therapy based on esomeprazole in the treatment of intractable peptic ulcer. Methods Eighty patients of intractable peptic ulcer were randomly divided into observation group and control group. Apart from amoxicillin and clarithromycin,colloidal bismuth pectin triple drug use,the drugs used by the patients in the observation group included esomeprazole,the control group included the omeprazole. The curative effects,relapse and Hp eradication rate of the patients in both groups were observed. Results The total effective rate and Hp eradicate rate of the observation group were higher than those of the control group( P 0. 05 or P 0. 01) ,while the recurrence rate was lower ( P 0. 05) . Conclusion Quadruple therapy based on esomeprazole which can effectively eradicate helicobacter pylori and reduce recurrence has better curative effects in the treatment of intractable peptic ulcer.