Anti-ulcer activity of Sandalwood (Santalum album L) stem hydro-alcoholic extract in three gastric-ulceration models of Wistar rats

Sandalwood (Santalum album L.) is used in various traditional systems of medicine, like Ayurveda, Siddha and Unani medicine to treat a wide range of ailments. In Unani medicine, Safed Sandal is used to treat gastric ulcers, hence the present study was undertaken to confirm this claim. A limit test as per OECD guidelines was conducted at a dose of 5000 mg/kg to determine the acute toxic dose of Hydro-alcoholic extract from S. album stem (SASE). Two test doses of SASE (250 and 500 mg/kg) were subjected to screening of anti-ulcer activity by three in-vivo models namely – water immersion - restrain stress, ethanol and indomethacin induced gastric ulceration models in albino wistar rats. A proton-pump inhibitor, Omeprazole 10 mg/kg and H2 receptor antagonist, Ranitidine 50 mg/kg were employed as standard drugs. The results revealed an increase in gastric protection as a significant decrease (p Sandalo (Santalum album L.) se utiliza en diversos sistemas de medicina tradicional, como el Ayurveda, Siddha y Unani para tratar una amplia gama de dolencias. En la medicina Unani, Safed Sandal se usa para tratar ulceras gastricas, por lo tanto, el presente estudio se realizo para confirmar esta afirmacion. Una prueba de limite segun las directrices de la OCDE se llevo a cabo a una dosis de 5000 mg/kg para determinar la dosis toxica aguda del extracto hidroalcoholico del tallo de S. album (SASE). Dos dosis de prueba de SASE (250 y 500 mg/kg) se sometieron al estudio de la actividad anti-ulcera por tres modelos in vivo, a saber: la inmersion en agua – estres de restriccion, y la ulceracion gastrica inducida por etanol e indometacina, en ratas Wistar albinas. Un inhibidor de la bomba de protones, omeprazol 10 mg/kg y el antagonista de los receptores H2, ranitidina 50 mg/kg fueron empleados como farmacos estandar. Los resultados revelaron un aumento de la proteccion gastrica como una disminucion significativa (p