[Clinical usefulness of immunocytochemical and genetic-molecular investigations in diagnosis of neoplasms of organs of sight].

AIM: To determine the usefulness of immunocytochemical (icch) and genetic-molecular (g-m) investigations in diagnosing neoplasm cases of eye, eye socket and eyeball, and to determine how far these investigations precise the diagnosis made using other methods. MATERIALS AND METHODOLOGY: 38 patients with neoplasm cases of eye, eye socket and eyeball were examined, performing routine ophthalmological examinations and auxiliary examinations such as USG, TK, roentgenography. Material for the cytological examination, icch and g-m, was obtained by way of fine needle biopsy (bac) in 18 patients with tumor of eye socket, conjunctiva or eyelid and in 1 patient with intraocular tumour. In the remaining patients with intraocular tumours print smears after eyeball removal were made. RESULTS: 100% conformability of cytological diagnoses, supplemented with icch evaluation, with the final diagnosis was found. The g-m examination made in 2 cases of lymphoma confirmed the clonal nature of the hyperplasia. CONCLUSIONS: Icch examinations make possible the diagnosis in cytological smear of histological type of mature and low-differentiated neoplasms. In tumours of eye and eye socket cases the diagnosis thus made allows to take a decision on conservative or operative therapy. In intraocular examinations these examinations find applications in diagnostically especially difficult cases.