Relative and absolute stereocontrol in intramolecular nitrone cycloadditions to the cyclohexene ring

Abstract The intramolecular reactivity of a nitrone derived from 2-(cyclohexen-3-yloxy)benzaldehyde has been investigated. By using ( R )- α -phenylethylamine as chiral auxiliary, enantiomerically pure (9-amino-substituted) 1,2,3,4,4a,9a-hexahydro-9 H -xanthen-1-ols were produced in satisfactory way.