Supervivencia de pacientes con tumores estromales gastrointestinales de intestino delgado

Introduction: Small intestine gastrointestinal stromal tumors have a very low incidence, and few national and international publications are available about the topic. Objective: Evaluate the overall survival of gastrointestinal stromal tumors in terms of their clinical and histopathological characteristics and their treatment. Methods: An observational retrospective study was conducted of 131 patients with small intestine gastrointestinal stromal tumors treated at Ameijeiras Hospital from 2003 to 2019. Overall survival was evaluated with the Kaplan-Meier method. Curves were compared using Log Rank and Breslow's tests with a significance level of 0.05 and a confidence interval of 95%. Results: A predominance was found of patients aged over 50 years, white skin color and good overall state. Mean tumor size was 11 cm. The most common metastatic sites were the liver and the peritoneum. Survival at five years was 78.3% (CI-95%:74.5; 82.1). Survival was higher in patients with tumor sizes of five cm or less, low mitotic counts, proliferative activity, localized disease, who could have their primary tumor removed, with appropriate margins, and without tumor rupture ( p = 0.01). Patients achieving complete response had four times more chances than those who only obtained stabilization of the disease ( p = 0.001). Conclusions: Patients with small intestine gastrointestinal stromal tumors in Cuba exhibit optimal survival rates, similar to the ones reported internationally. Key words: gastrointestinal stromal tumors, GIST, epidemiology, small intestine, survival.