Does lemon juice increase radioiodine reaccumulation within the parotid glands more than if lemon juice is not administered

Objective The protective effect of sialagogues following I therapy became controversial after a study proposed that sialagogues increase the reaccumulation of I in the parotid glands (PGs) to a level higher than when sialagogues are not administered (‘rebound effect’). The present study examined PG radiopharmacokinetics within 2–4 h after radioiodine administration to evaluate whether sialagogues cause a ‘rebound effect’.