Effectiveness of vitamin B12 in combined system disease; rapid regression of neurologic manifestations and absence of allergic reactions in a patient sensitive to injectable liver extracts.

IT IS well known that in patients with pernicious anemia, adequate therapy with desiccated stomach, whole liver and liver extracts for oral use, or with crude or refined liver extracts given by injection, will arrest the progress of combined system disease and may bring about a variable amount of recovery of nervous function, depending on the duration and severity of the process.1 Since in many patients the neurologic and hematologic manifestations of pernicious anemia differ strikingly in degree, the possibility exists that these abnormalities are due to deficiency of two different substances, both of which are contained in the therapeutic . . .