Influence of augmentation atorvastatin treatment early on the serum lipid and C reactive protein in patients with acute coronary syndrome

Objective:To investigate the influence of augmentation atorvastatin treatment early on the serum lipid and C reactive protein (CRP)in patients with acute coronary syndrome and its safely.Methods:Total of 72 patients were divided into two groups randomly:atorvastatin control group (group A,atorvastatin was 10 mg/d based routine therapy)and augmentation atorvastatin group(group B,atorvastatin was 40 mg/d based routine therapy).Therapeutic time was 4 weeks.Serum total cholesterol (TC),low density lipoprotein-cholesterol (LDL-C)and CRP contents were measured before and after therapy.Results:After therapy,the serum lipid and CRP levels all significantly decreased in two groups(P0.05～0.01),but compared with group A,the CRP [(16.45±6.45) mg/L vs.(11.48±6.83) mg/L],TC [(5.38±0.64) mmol/L vs.(4.92±0.50)mmol/L],LDL-C [(2.53±0.46)mmol/L vs.(1.95±0.39) mmol/L],were more decreased(P0.05 all) in group B.There were no serious harmful event in two groups.Conclusion:Augmentation atorvastatin treatment may more decrease CRP and serum lipid levels and is safe.