DEVELOPMENT AND VALIDATION OF UV SPECTROMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF ULIPRISTAL ACETATE Short Communication

Objective: To develop and validate UV spectrometric method for quantitative determination of ulipristal acetate. Methods: The solvent selected was methanol and detection was carried out at 302 nm. Results: Linearity of the proposed method was found to be between 5–20 μg/ml. LOD and LOQ were found to be 0.0062 μg/ml and 0.0187 μg/ml, respectively. The % recovery of the proposed method was found to be 98.83 %-100.32 %. The method was found to be precise as the values of % RSD obtained for both intraday and interday, precision studies were found to be<2.0 %. The method was robust and can be useful for routine analysis of formulations containing ulipristal acetate. Conclusion: The developed method was found to be simple, sensitive, linear, accurate, precise and robust. The developed and validated method can be used for quantitative determination of ulipristal acetate in bulk drugs and dosage form.