Direct Catalytic Asymmetric Vinylogous Mannich-Type and Michael Reactions of an α,β-Unsaturated γ-Butyrolactam under Dinuclear Nickel Catalysis
2010
Direct catalytic asymmetric vinylogous reactions of an α,β-unsaturated γ-butyrolactam as a donor are described. A homodinuclear Ni2-Schiff base complex promoted a vinylogous Mannich-type reaction of N-Boc imines as well as a vinylogous Michael reaction to nitroalkenes selectively at the γ-position under simple proton-transfer conditions. Vinylogous Mannich adducts were obtained in 5:1→30:1 dr and 99% ee, and vinylogous Michael adducts were obtained in 16:1→30:1 dr and 93−99% ee.
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