Identification of local determinants of DNA interstrand crosslink formation by cyclophosphamide metabolites

Frederick H. Hausheer,U. C. Singh,Saxe Jd,O. M. Colvin

Identification of local determinants of DNA interstrand crosslink formation by cyclophosphamide metabolites

1989

Frederick H. Hausheer
U. C. Singh
Saxe Jd
O. M. Colvin

Specific interactions between DNA and cyclophosphamide metabolites determining formation and stabilization of interstrand crosslinks have been identified by advanced molecular computational methods

Keywords:

Alkylation
Biochemistry
Nucleic acid
DNA
Mechanism of action
Metabolite
Chemistry
Cyclophosphamide
Thymine
DNA sequencing
Guanine
Adduct

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