Gastric acid secretion and experimental ulceration in rats fed soybean diet preparations

Effects of different preparations of Soybean diet on histamine or carbachol-induced acid secretion and indomethacin ⠀ induced ulceration were studied in male albino Wister rats. The animals were divided into four dietary groups (groups I, II, III and IV) and fed normal rat diet, 75% soybean diet, 50% soybean diet and 25% soybean diet respectively. Rats in group I served as control. After six weeks of feeding, acid secretion studies using histamine (3mg/Kg) or carbachol (50μg/Kg) and ulcer studies were carried out. While histamine and carbachol produced 400% and 350% increases respectively in acid output in rats fed normal diet, the acid output in soybean diet fed rats were between 210% and 280%. Also, rats fed soybean diets had lower ulcer scores than rats fed normal diet. Indeed, the higher the concentration of soybean in the diet the lesser the ulcer scores. The results therefore seem to suggest that soybean has buffering effect on induced acid secretion and protect the stomach against ulcer formation. Keywords : soybean, acid secretion, ulcers, rats African Journal of Biomedical Research Vol. 8(3) 2005: 203-205