Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes.

Jan W. Buikema,Soah Lee,William R. Goodyer,Renee G. Maas,Orlando Chirikian,Guang Li,Yi Miao,Sharon L. Paige,Daniel Lee,Haodi Wu,David T. Paik,Siyeon Rhee,Lei Tian,Francisco X. Galdos,Nazan Puluca,Benjamin M. Beyersdorf,James B. Hu,Aimee Beck,Sneha Venkamatran,Srilatha Swami,Paul J.M. Wijnker,Maike Schuldt,Larissa M. Dorsch,Alain van Mil,Kristy Red-Horse,Joy Y. Wu,Caroline Geisen,Michael Hesse,Vahid Serpooshan,Stefan Jovinge,Bernd K. Fleischmann,Pieter A. Doevendans,Jolanda van der Velden,K. Christopher Garcia,Joseph C. Wu,Joost P.G. Sluijter,Sean M. Wu

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes.

2020

Summary Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in vitro can expand CMs modestly (

Keywords:

Induced pluripotent stem cell
Wnt signaling pathway
Biology
Cell biology
Cardiomyocyte proliferation
cell cell contact
Signal transduction

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