Compound inhibiting glutathion S-transferase activity, preparation and use thereof

The invention discloses five known compounds for inhibiting glutathione S-transferase (GSTs) activity, and an application of the compounds in tumor adjuvant treatment. The known compounds are GSTs activity inhibiting compounds, which comprise (Z)-ligustilide, angelic acid(z)-ligustilide-11-alcohol ester, Tokinolide B, coniferylfemlate, (3Z, 3Z')-6, 8', 7, 3'dual-ligustilide. In vitro screening experiments show that the compounds have good inhibitory activity for GSTs and are clear in inhibition type. The GST plays an important role in tumor multidrug resistance reversal by inhibiting the activity of the GST. Thus, the sensitivity of tumors to the anti-tumor medicines is improved and the medicine resistance of tumor cells to the anti-tumor medicines is reversed.