Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats.

ObjectivesMethylglyoxal is a reactive dicarbonyl intermediate of metabolism produced in the body. It reacts with certain proteins and forms damaging advanced glycation endproducts (AGEs) such as Ne-carboxyethyl-lysine (CEL) and Ne-carboxymethyl-lysine (CML). Increased methylglyoxal levels are found