The effect of anti-anxiety drugs on the clinical symptoms of anal fissure: A randomized clinical trials

Background: Fissure is a common chronic anorectal disease which causes symptom such as pain, burning, bleeding and psychiatric problems. One of the psychiatric complications is anxiety, which might be an etiologic factor or secondary to the illness. Materials and Methods: After obtaining patient consent and demographic data, 160 patients with anal fissure were divided randomly into two groups (80 patients treated with anti-anxiety drugs along with standard anal fissure treatment and 80 patients with standard anal fissure treatment alone), and symptoms have recorded after treatment. Results: Our study results showed that the administration of anti-anxiety drugs in patients with anal fissures relieved pain and anxiety scores among all patients. The anti-anxiety drug's effect was more effective on patients younger than 40 years, men with less than two weeks duration of illness, and baseline anxiety greater than 26. Conclusion: A high prevalence of anal fissures affects illness on patients' quality of life. Besides the lack of effective treatment that shortens the pain and recovers patients faster, anti-anxiety drugs such as benzodiazepines can use along with standard anal fissure treatment to reduce pain and anxiety in patients with acute anal fissure.