Treatment of peptic ulcer of the gastroduodenal area with the antioxidant dibunol and the change in antioxidant activity of erythrocyte lipids in patients during treatment

: Variation in the AOA of red cell lipids in peptic ulcer of the gastroduodenal zone was studied before and after treatment. Dibunol was administered by local applications of a 20% oily solution in a dose of 5 ml every other day with the aid of a fibroscope. The AOA was measured in experimental oxidation of methyl oleate in 20 normal subjects. In 25 patients, it was measured before treatment and 14 days after instituting local therapy. Twenty-five patients with peptic ulcer received treatment. In 96% of the patients, the ulcers healed. In the majority of the patients, the healing took place at early times. The healing occurred according to the "mucosal" type. In all the patients, the AOA was considerably less than normal before treatment. During dibunol treatment, the patients were divided into 2 groups according to the changes in the AOA. The first group (15 patients) manifested an increase in lipid AOA, rapid cicatrization of the ulcerous defect, favourable long-term results. The 2nd group (10 patients) showed a lowering of lipid AOA as compared with the initial level, which correlated with more prolonged times of ulcer cicatrization and a greater number of relapse at early times, though the results of dibunol treatment in the 2nd group patients were also considerably better than those obtained with conventional therapy.