Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: synthesis, biological evaluation, and structure-activity relationships.

Abstract The synthesis and evaluation of new analogues of thieno[2,3- d ]pyrimidin-4-yl hydrazones are described. 2-Pyrdinecarboxaldehyde [6 - ( tert -butyl)thieno[2,3- d ]pyrimidine-4-yl]hydrazone derivatives have been identified as cyclin-dependent kinase 4 (CDK4) inhibitors. The potency, selectivity profile, and structure–activity relationship of this series of compounds are discussed.