Development of integrin inhibitors in antitumor therapy

Integrins are transmembrane glycoprotein receptor on cell surface, which can mediate adhesion between cells and involve in angiogenesis and tumor metastasis. Therefore, integrins are closely related with tumorigenesis and tumor development. Integrin-targeted anti-tumor therapy could effectively inhibit tumor growth and metastasis. This review mainly focused on development of integrin inhibitors in antitumor therapy in recent years from aspects of anti-tunor growth, anti- tumor metastasis, anti-angiogenesis and so on. Further more, dual function of doses in integrin-targeted therapy are also discussed.