Skin carcinogenesis: the pathogenetic and therapeutic role of zinc

are associated with high-dose intermittent UVR, and there are even types of CMM that are not related to sunlight [2]. The incidence of CMM is 4-19 per 100000 individuals in Europe [3], and many patients are younger than 40 years old. Hereditary factors that affect skin pigmentation, DNA repair efficacy, and immune response play a very important role in the pathogenesis of CMM. CMM is characterised by a high propensity to metastasise and a low healing rate in metastatic cases. Surgery is the mainstay of skin cancer therapies. Topical and systemic medications are used to treat very early or advanced stages of the disease.