Study on Biomaterials of Anti-Gastric Trametenolic Acid B Semi-Synthetic Derivatives

Discovery of bioactive ingredients from plants and fungi is always the hot spots in medicinal chemistry. The trametenolic acid B was a bioactive lanostane-type triterpenoid in Trametes lactinea (Berk.) Pat. In this work, four semi-synthetic derivatives were synthesized, characterized and evaluated the anti-gastric cancer activities against HGC-27 cells with the aim of obtaining better anti-tumor agents. The compounds 2a and 3b possessed good anti-proliferative effects under normal physiological conditions, and their anti-cancer effects increased as the pH decrease to 5.5 with the IC50 of 17.55 and 10.63 μM, respectively. These compounds might be further developed as anti-gastric cancer drugs.