Relationship between gram-negative bacteria and nosocomial infections in neurological intensive care unit

OBJECTIVE To analyze the distribution of the gram-negative in neurological intensive care unit environment and the clinical characteristics of nosocomial infection patients in neurological intensive care unit,so as to institute prevention strategy for nosocomial infection caused by G-bacteria.METHODS All inpatients admitted to neurological intensive care unit of the hospital from Dec.2010 to Sep.2011were collected as monitoring objectives.The results of pathogen identification and drug susceptibility test were recorded.The microbiological characteristics of indoor environment(air-environment and the bed-unit) of the ward were also monitored.RESULTS During the study period,there were 61 patients got nosocomial infection among all 209 monitoring objectives,the incidence was 29.2%.42 patients received the pathogenic examination,and G-bacteria accounted for 77.9%.Among the gram-negative bacilli,K.pneumoniae and P.aeruginosa accounted for 25.9% and 23.3% respectively.They were both susceptible to levofloxacin.Bacteria were also detected in ward environment,most of them were gram-negative bacilli,especially ABA.There was no difference of the distributions among indoor air,pillow and quilt(P0.05).CONCLUSION Gram-negative bacilli are the predominate pathogens in the NICU which would cause nosocomial infections.Lower respiratory tract is the most susceptible location,the major pathogens are K.pneumoniae and P.aeruginosa.The NICU ward environment is one of the most important transmission routes of gram-negative bacilli but not K.pneumoniae.The K.pneumoniae is susceptible to most antibiotic,other gram-negative bacilli have different levels of antimicrobial resistance.