Impaired Glucose Metabolism and Reduced Insulin Clearance in Elderly Hypertensives

Diabetes mellitus and essential hypertension are characterized by a continuous rise of prevalence with aging and this association may not be casual. Thirty nonobese nondiabetic elderly patients with primary hypertension and 28 healthy normotensives matched for age, sex, and body weight were evaluated for insulin secretion (oral glucose tolerance test, day-long glycemic and insulinemic profiles), action (euglycemic moderately hyperinsulinemic glucose clamp auociated with 3 H-3-glucose dilution technique), and clearance (120 min insulin/glucose infusion at two prefixed doses