Hypolipidemic action of a new aryloxy compound (S-8527) in rats

Abstract The effect of 1,1-bis[4′-(1′-carboxy-1′-methylpropoxy)-phenyl]cyclohexane (S-8527) on serum and liver lipids was studied in rats and compared with clofibrate. When rats were given a daily oral dose of 10 mg/kg or 30 mg/kg of S-8527 for 14 days, marked reduction of serum cholesterol and triglycerides was observed and the decreases were more pronounced than those in rats treated with 100 mg/kg or 300 mg/kg of clofibrate. There was no significant increase in liver weight, while clofibrate caused significant hepatomegaly. A similar hypolipidemic effect was observed when S-8527 was given mixed in the diet at concentrations of 0.01% or 0.03% and a more marked effect was noted in rats fed on a semisynthetic diet that contained sucrose as the only carbohydrate source. S-8527 lowered the hepatic triglyceride level but slightly raised the cholesterol level.