Early kidney transplantation may prevent aluminium-related bone disease

In uraemia patients aluminium (Al) accumulation in bone leads to low turn-over bone disease [4]. Al-related bone disease causes bone pain, non-traumatic fractures and hypercalcaemia, and does not respond to treatment with vitamin D compounds [9]. Al-contaminated dialysate and ingestion of Al-containing phosphate binding agents are the main risk factors for bone Al accumulation [6, 12].