Inhibitory Effect of MCI-186, a Free Radical Scavenger, on Cerebral Ischemia Following Rat Middle Cerebral Artery Occlusion
1998
1.
In this study, we investigated the effect of a radical scavenger, MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one), on cerebral damage induced by rat middle cerebral artery (MCA) occlusion, and further measured the hydroxyl radical level at the ischemic border zone using a microdialysis technique.
2.
MCI-186, at a dose of 3 mg/kg per 30 min, was administerated as a continuous infusion two times for 30 min, starting 20 min and then 80 min after Rose Bengal injection.
3.
MCI-186 significantly (P<0.05) reduced size of cerebral damage 24 hr after MCA occlusion and significantly (P<0.05) reduced hydroxyl radical level.
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