Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children
2007
Abstract Oral lactoferrin supplementation in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naive children resulted in a skewing of T-lymphocytes towards more differentiated subpopulations. Phagocytosis ( P = 0.01) and killing ( P = 0.009), Toll-like receptor 2 expression ( P = 0.01) and the interleukin-12/interleukin-10 ratio ( P = 0.001) were also improved by lactoferrin. Lactoferrin supplementation results in immune modulation and could be useful in HIV infection.
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