Hemolytic resistance of erythrocytes in the development of experimental tumors

: Peculiarities of variations in the mechanical resistance of erythrocytes from mice with tumours were studied depending on the growth stage of tumours (lymphoma NK/Ly and sarcoma S-37). The accumulation of erythrocytes with the increased mechanical resistance at the stage of rapid tumour development (on the 4 to 6th days) was revealed by the kinetic method of ultrasonic haemolysis. Quantitative parameters of ultrasonic haemolytic resistance of erythrocytes from normal and tumour-bearing mice were used as criteria for the red blood cell changes depending on the cell age in blood. The increase of haemolytic resistance at the rapid stage of tumour growth may be caused by a higher number of "young" erythrocytes in blood. Ultrasonic haemolytic resistance increases when there is no changes in the erythrocyte quantity and hemoglobin concentration. The kinetic study of ultrasonic haemolysis of the erythrocytes isolated from peripheric blood permits estimating the reaction of the blood forming organs to the origin and development of tumours.