Detección de la liberación del Fluconazol cargado en un Adhesivo Protésico

The total loss of teeth mostly causes alterations in the oral cavity as changes at the level of the mucosa and alveolar bone, clinical situations that alter the correct prosthetic functionalism. The use of adhesives gives patients physical and psychological security against detachment of the prosthesis, and promotes chewing. To combat different pathologies present in oral cavity caused by dentures, it should be prescribed antifungal topical and systemic, effectively eliminating the aggressor microorganism, but also affecting normal cells, achieving an aggressive, no selective effect. For this aim it is proposed to determine the release of fluconazole loaded on a prosthetic adhesive through an electro-chemical system. Thus ensuring comply with mechanical and antifungal functions. Thus an experimental descriptive research was conducted. The procedure initiated by diluting the contents of a capsule Diflucan®, with an alkaline pH buffer substance, which was placed in the electrochemical cell, while measuring the current-potential curve of release, the content of fluconazole was mixed with Corega® again placing the cell and electrochemical analysis to proceed for a period of five hours. three observations through the optical microscope were made and verifying adherence to the base and the compound miscibility. It was found that fluconazole was released to the media in a 65.96% at five and a half hours, concluding effective drug release or attached to the prosthetic adhesive using differential pulse voltammetry.