注射薬配合変化を考慮した側管投与におけるフラッシング条件の検討(第3報) : アレビアチン^[○!R]注を用いたフラッシング条件の検討

Flushing is performed mainly to avoid compositional changes in the flow passage when drugs are administered by the I.V.push or piggyback infusion methods.This is done by injecting rinsing solutions,such as physiological saline or glucose solution,through side tubes before and after administration of drugs to dilute or replace them in the flow passage.In this study,we examined the flushing conditions for phenytoin sodium injection (Aleviatin® injection) and the effect of its viscosity on flushing.Aleviatin® injection is highly viscous and there is a high risk of compositional changes with it.For effective flushing,we found that the flushing volume depended on the volume of the tube and that it was necessary to use a volume of 15mL to 40mL of the rinsing solution.It was also noted that the viscosity of the injection solution affected the effectiveness of flushing.