Study on intestinal absorption of multiple constituents under the drug response of Wuwei-Jiangya recipe

Objective To research the intestinal absorption characteristics in rats of multiple constituents,when Wuwei-Jiangya recipe was used in rats and showed reducing blood pressure effects.Methods ① After extracting Wuwei-Jiangya recipe,we fed it to rats once daily,until the blood pressure reduced; ②Establish Wuwei-Jiangya recipe and intestinal absorption of multiple constituents fingerprint by using reverted gut sac method and RP-HPLC fmgerprint.Results After one week's administration,there was the hypotensive effects and multiple constituents can be absorbed by intestine.Conclusion When the drug works,reverted gut sac method for studying intestinal absorption constituents can be used for locking the exposure constituents. Key words: Wuwei-Jiangya recipe;  Exposure-response;  Multicomponent;  Fingerprint