Hybrid modelling of mechanical cues in cell migration

Many studies stress the crucial importance of the mechanical component in angiogenesis, but still very few models really integrate mechanics. We propose to inves- tigate the importance of mechanical cues for cell migration in this context with a new hybrid continuous-discrete model that describes the individual migration of contracting cells on an elastic matrix of fibres. The matrix is described as a continuum substrate whereas the cells are described as discrete elements.