Selective degradation of splicing factor CAPERα by anticancer sulfonamides

Taisuke Uehara,Yukinori Minoshima,Koji Sagane,Naoko Hata Sugi,Kaoru Ogawa Mitsuhashi,Noboru Yamamoto,Hiroshi Kamiyama,Kentaro Takahashi,Yoshihiko Kotake,Mai Uesugi,Akira Yokoi,Atsushi Inoue,Taku Yoshida,Miyuki Mabuchi,Akito Tanaka,Takashi Owa

Selective degradation of splicing factor CAPERα by anticancer sulfonamides

2017

Taisuke Uehara
Yukinori Minoshima
Koji Sagane
Naoko Hata Sugi
Kaoru Ogawa Mitsuhashi
Noboru Yamamoto
Hiroshi Kamiyama
Kentaro Takahashi
Yoshihiko Kotake
Mai Uesugi
Akira Yokoi
Atsushi Inoue
Taku Yoshida
Miyuki Mabuchi
Akito Tanaka
Takashi Owa

A series of sulfonamides induced the ubiquitin-mediated degradation of the U2AF-related splicing factor, coactivator of activating protein-1 and estrogen receptor α (CAPERα), by promoting direct binding between CAPERα and the CRL4 substrate receptor DCAF15.

Keywords:

Molecular biology
Biochemistry
Estrogen receptor
Substrate (chemistry)
Splicing factor
Biology
Coactivator
Receptor
direct binding
selective degradation

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