Male Sexual Dysfunction Efficacy and Safety of Tramadol for Premature Ejaculation: A Systematic Review and Meta-analysis

We identified 7 publications that strictly met our eligibility criteria. Meta-analysis of extractable data showed that tramadol was associated with a 3-minute intravaginal ejaculation latency time increasing (mean difference 2.77 minutes; 95% CI 1.12-4.47; P .001) and significantly more patients with adverse events rates compared with placebo (odds ratio 2.89; 95% CI 1.88-4.43; P .0001). There were no differences between the tramadol and the paroxetine of intravaginal ejaculation latency time (mean difference 0.44; 95% CI 5.07 to 4.18; P .85). In addition, patients saw significantly greater improvement in patient-reported outcome. CONCLUSION In this diverse population, tramadol is an effective and safety pharmacologic therapy for premature ejaculation. UROLOGY 80: 618‐624, 2012. © 2012 Elsevier Inc.