The significance of the hemalexin C1q, RBP, and urinary NAG levels in the diagnosis and prognosis of children with purpura nephritis.

Purpose: To investigate the significance of the hemalexin C1q, retinal-binding-protein (RBP), and urinary N-acety1-β-D-glucosaminidase (NAG) levels in the diagnosis and prognosis of children with purpura nephritis. Methods: A total of 130 children with purpura nephritis admitted to our hospital from January 2017 to December 2019 were recruited as the study cohort, including 43 children with purpura nephritis as the observation group, 51 children with purpura nephritis as the control group, and 36 healthy children undergoing physical examinations at the same time period as the healthy group. The basic data of the three groups of children were compared, and the hemalexin C1q, RBP, and urinary NAG levels were observed. The children were divided into a good prognosis group and a poor prognosis group according to the observation group’s follow-up data. The significance of the hemalexin C1q, RBP, and urinary NAG levels for the diagnosis and prognosis of children with purpura nephritis was investigated by comparing the hemalexin C1q, RBP, and urinary NAG levels in these two groups. Results: The hemalexin C1q, RBP, and urinary NAG levels in the observation group, the control group, and the healthy group were significantly reduced, and the differences were statistically significant (P < 0.05). The hemalexin C1q, RBP, and urinary NAG levels of the children in the good prognosis group were significantly lower than they were in the poor prognosis group (P < 0.05). Conclusion: The hemalexin C1q, RBP, and urinary NAG levels in the diagnosis and prognosis of children with purpura nephritis have a definite value and can be used as effective predictors for the prognosis of children with purpura nephritis.