Hypersensitivity vasculitis complicating intravenous streptokinase therapy in acute myocardial infarction

A 52-year-old man developed a hypersensitivity vasculitic rash on his legs nine days after receiving intravenous streptokinase therapy for acute myocardial infarction. The histological and immunological features and the differential diagnosis of this unusual complication of streptokinase therapy are reviewed.