Experimental Basis for Optimal Regimnes of Hyperthermic Peritoneal Chemotherapy

Temperature exposure reliably inhibits tumor cell potential for proliferation at the temperature of not less than 43 °C only. Temperature regimens recommended for clinical treatment (40–42 °С) have no significant impact on the viability of tumor cells. Tumor growth arrest in murine models was observed only in case of preliminary warming of inoculated cells at a temperature more than 42 °С. Heating tumor cells up to 39 °С and their incubation with anticancer drugs in the mean-effective concentrations enhanced tumor cell sensitivity towards cytotoxic action of activated lymphocytes.