Stereoselective α-indolylation of enals via an organocatalytic formal cross-coupling with indoles
2015
We report a novel organocatalytic one-pot cascade bromination–Michael-type Friedel–Crafts alkylation dearomatization–nucleophilic rearrangement aromatization cascade process for the direct α-indolylation of unfunctionalized enals from readily available indoles with good yields and high E selectivity. The simplicity and practicality of its high efficiency for formation of a new C(sp2)–C(sp2) bond constitute the most attractive advantage of this reaction.
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