TEACHERS' TOPICS The Pharmacology of Immunosuppression

SUMMARY A comprehensive, integrated presentation on thepharmacology of immuosuppression was presented in in-tegrated sequence modules that included content frompharmacology, medicinal chemistry, and therapeutics.Grades on comprehensive examinations and in-classquizzes indicated the students had achieved a thoroughunderstanding of all aspects relating to immunosuppres-sive therapy. REFERENCES 1. Allison AC. Immunosuppressive drugs: the first 50 years anda glance forward. Immunopharmacol. 2000;47(5):63-83.2. Chisholm MA, Mulloy LL, Jagadeesan M, DiPiro JT. Impactof clinical pharmacy services on renal transplant patients’ compliancewith immunosuppressive medications. Clin Transplant.2001;15(2):330-336.3. Fishman JA, Rubin RH. Infection in organ-transplant recipients.N Engl J Med. 1998;338(24):1741-1751.4. Hesselink DA, vanGelder T, van Schalk RHN. Thepharmacogenetics of calcineurin inhibitors: one step closer towardindividualized immunosuppression. Pharmacogenomics.2005;6(4):323-337.5. United Network for Organ Sharing. http://www.unos.org.Accessed October 21, 2009.6. Rifle G, Mousson C, Laurent M, Guignier F, Kais H. Donor-specific antibodies in allograft rejection: clinical and experimentaldata. Transplantation. 2005;79(3):S14-S18.7. Heeger PS. T-cell allorecognition and transplant rejection:a summary and update. Am J Transplant. 2003;3(5):525-533.8. Libby P, Pober JS. Chronic rejection. Immunity. 2001;14(4):387-397.9. Allison AC, Eugui E. Mechanisms of action of mycophenylatemofetil in preventing acute and chronic allograftrejection. Transplantation. 2005;80(2S):S181-S190.10. Brooks RJ, Dorr RT, Durie BG. Interaction of allopurinol with6-mercaptopurine and azathioprine. Biomed Pharmacother.1982;36(4):217-222.11. Marshall SE, Welsh KI. The role of cytokine polymorphisms inrejection after solid organ transplantation. Genes Immun.2001;2(6):297-303.12. Kapturczak MH, Meier-Kriesche HU, Kaplan B. Pharmacologyof calcineurin antagonists. Transplant Proc. 2004;36(2):25-31.13. Sehgal SN. Sirolimus: its discovery, biological properties andmechanism of action. Transplant Proc. 2003;35(3):7-14.14. Rhen T, Cidlowski JA. Antiinflammatory actions ofglucocorticoids – new mechanism for old drugs. N Engl J Med.2005;353(16):1711-1723.15. Davidson A, Diamond B. Autoimmunity. N Engl J Med.2001;345(5):340-350.16. Bloom BS. Taxonomy of Educational Objectives. Handbook 1:Cognitive Domain. New York: David McKay Co, Inc; 1956.17. Wongwiwatthananukit S, Popovich NG, Bennett DE. Assessingpharmacy student knowledge on multiple-choice examinations usingpartial-credit scoring of combined-response multiple-choiceitems. Am J Pharm Educ. 2000;64(2):1-10.18. Regazzi MB, Alessiani M, Rinaldi M. New Strategies inImmunosuppression. Transplant Proc. 2005;37(6):2675-2678.19. Golan DE, Tashjian AH, Armstrong EJ, Armstrong AW.Principles of Pharmacology: The Pathophysiologic Basis of DrugTherapy.of Drug Therapy. 2nd Edition. Philadelphia, Penn: WoltersKluwer/Lippincott Williams & Wilkins. 2008:795.20. Katzung BG, Masters SB, Trevor AJ. Basic and ClinicalPharmacology. 11