Influence of lubricant properties on compression behaviour and drug dissolution rate of scleroglucan hydrophilic matrix
1995
Abstract The present work was undertaken to investigate the effect of lubricant hydrophobicity level on the pharmacotechnical and dissolution behaviour of a scleroglucan hydrophilic matrix. Sodium stearyl fumarate Pruv® was compared to magnesium stearate. The influence of the amount of lubricant on the compression behaviour of the matrix was considered. The relationship between an increase in the polymer concentration and lubricant on dissolution rate was also studied. A statistical approach was made to evaluate the significant level of lubricant influence on drug dissolution. It was found that even at a level of 0.5%, the lubricant can influence both the compression ability and drug dissolution rate of scleroglucan hydrophilic matrix.
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