Synthesis of [11C]salicylic acid and related compounds and their biodistribution in mice.

Abstract For in vivo measurement of the hydroxyl radical ( % s OH), we synthesized [ 11 C]salicylic acid, [ 11 C]O-acetylsalicylic acid and [ 11 C]2-methoxybenzoic acid by carboxylation of 2-bromomagnesiumanisol using [ 11 C]CO 2 . The radiochemical yield of [ 11 C]salicylic acid, [ 11 C]O-acetylsalicylic acid and [ 11 C]2-methoxybenzoic acid calculated from trapped [ 11 C]CO 2 in a liquid argon cooled stainless tube was 7.3±1.6, 5.2 and 10.2±1.7% (decay corrected), respectively. The uptake of 11 C tracers by mouse brain was 0.46, 0.32 and 0.46% dose/g tissue, respectively, at 10 min post injection and presented washout patterns thereafter.