TRIM5α H43Y Polymorphism and Susceptibility to HIV-1 Infection: A Meta-Analysis.

Abstract TRIM5α is an antiviral factor that can greatly limit HIV-1 infection. Although several researchers have investigated whether TRIM5α H43Y polymorphism influences the risk of HIV-1 infection, no definite conclusion has ever been drawn. In this research, we performed a meta-analysis to generate a more robust estimate of the association between TRIM5α H43Y and susceptibility to HIV-1 infection. In total, six studies including 1,713 HIV-1 patients and 1,814 controls were included. TRIM5α H43Y polymorphisms of all individuals were genotyped. Odds ratios (ORs) with 95% confidence intervals were presented as the result of analysis. ORs for the main analysis were 0.82 (95% CI: 0.63–1.08) in the allelic comparison, 0.57 (95% CI: 0.34–0.95) in the homozygote comparison, 0.82 (95% CI: 0.57–1.16) in the dominant model, and 0.56 (95% CI: 0.33–0.93) in the recessive model. In the subgroup analysis by ethnicity, significantly decreased risks of infection were detected in the Asian population (homozygote comparis...