Synthesis method Emamectin Benzoate

The present invention provides a kind of avermectin derivatives of the avermectin derivatives having a sulfonyl group in avermectin C4 "position. The present invention also provides a preparation method and kind of the avermectin derivative method for preparing the amide derivatives of avermectin present invention provides synthetic processes further progress kinds of emamectin benzoate above technical solution, the present invention can simplify the manufacturing process, reduce production costs, reduce by-product emissions;. further, the avermectin starting material, mono- protected - sulfonic ester - amination - deprotection - benzoic acid salified five steps procedure, the same solvent may be used, instead of replacing the solvent, thereby improve production efficiency, reduce production costs; in addition, the method of the present invention may not use the C4 - step 'hydroxyl is oxidized to C4 "carbonyl group, so as to avoid malodor and catalyst B poisoned condition due to sulfur-containing impurities generated effectively reduce waste gas emissions and reduce the amount of catalyst B.