2-Hydroxy-5-(ethanolamino)-3-(10'-Z-pentadecenyl)-1, 4-benzoquinone, New Microbial Phase II Metabolite of Maesanin

The use of microbial models for biotransformation of the natural benzoquinone, maesanin (1), resulted in the isolation of an ethanolamine conjugate (5) from the culture broth of Debaryomyces polymorphus ATCC 20280. Metabolite 5 was characterized as 2-hydroxy-5-(ethanolamino)-3-(10'-Z-pentadecenyl)-1, 4-benzoquinone. The production of 5 represents a new type of phase II conjugation reaction in microbial systems. The results of preliminary mammalian metabolism of 1 in rats were incondlusive.