Meta-analysis of NFKB1 -94 ATTG ins/del polymorphism and risk of breast cancer.

BACKGROUND: Breast cancer (BC) accounts for one of the most prevalent malignances the world. Inflammatory molecules modulate tumor microenvironment in BC that promotes tumor growth and metastasis. NF-kappaB (a transcription factor) that regulates multiple immune functions and acts as a crucial mediator of inflammatory responses. OBJECTIVE: The present study is aimed to quantitatively summarize the relation of NFKB1 -94 ATTG (I, insertion/D, deletion) variant and risk of BC. MATERIALS AND METHODS: Further, the meta-analysis includes three independent case-control investigations that focus on NFKB1 -94, ATTG I/D polymorphism, and BC patients. Web of Science, PubMed and Embase databases were used to retrieve relevant data. OR and 95% confidence interval of pooled studies were analyzed by using the MetaGenyo web tool. RESULTS: This study revealed high heterogeneity. In all three genetic comparison models, the NFKB1 -94 ATTG I/D variant is not related with the risk of BC. Further, no publication bias on the connection between NFKB1 -94 ATTG I/D variant and risk of BC. CONCLUSION: To summarize, our meta-analysis demonstrates that the NFKB1 -94 ATTG I/D polymorphism is not a major risk factor for BC.