A 6-Month, Prospective, Randomized Controlled Trial of Customized Adherence Enhancement Versus Bipolar-Specific Educational Control in Poorly Adherent Individuals With Bipolar Disorder

Objective: Non-adherence in bipolar disorder (BD) ranges from 20–60%. Customized adherence enhancement (CAE) is a brief, BD-specific approach that targets individual adherence barriers. This prospective, 6-month, randomized controlled trial compared CAE vs. a rigorous BD-specific educational program (EDU) in poorly-adherent individuals on adherence, symptoms, and functional outcomes.