349-OR: Pancreas Volume Is Smaller in Individuals with Stage 1 Type 1 Diabetes (T1D) and Correlates with Disease Progression

Pancreas size is smaller at the onset of T1D and in individuals at risk for T1D, as measured by MRI. To determine whether pancreas volume predicts T1D progression, we measured pancreas size and dynamics in Type 1 Diabetes TrialNet Pathway to Prevention study participants with Stage 1 T1D, as defined by the presence of two or more autoantibodies and normal glucose tolerance. Individuals with Stage 1 T1D (n = 25, median age = 13.9 y.o.) exhibited a smaller pancreas volume than controls without T1D (n = 34, median age = 15.2 y.o, p Disclosure J. Virostko: None. J.M. Williams: None. M.A. Hilmes: None. J.J. Wright: None. B.D. Hammel: None. L. Du: None. H. Kang: None. W.E. Russell: None. A.C. Powers: None. D.J. Moore: None. Funding JDRF (3-SRA-2019-759-M-B, 3-SRA-2015-102-M-B)