Ligustrazin Regulates Expression of Type III Procollagen in Spontaneously Diabetic Nephropathy Rats

Objective:To observe the Ligustrazin regulated the expreeion of procollagen Ⅲ in spontaneous diabetic nephropathy rats.Methods:Six months pecefic pathogen free(SPF) GK rats and Wistar rats were allocated to normal control group,model group,and Ligustrazin group for 16 weeks..After the treatment,the general state,blood urea nitrogen,serum creatinine,dvanced glycosylation end products,urinary albumin excretion rate of the 24-hours,and clearance rate of creatinine,as well as type the protein expreeion of procollagen Ⅲ were determined by immunohistochemistry analysis in the kidney tissue of different groups.Results:① Diabetes mellitus and renal function lesion occurred in the two model groups.② Ligustrazin could improve the general state of spontaneous diabetic nephropathy rats,decrease blood urea nitrogen,serum creatinine,dvanced glycosylation end products,and urinary albumin excretion rate of the 24-hours;increase clearance rate of creatinine,The protein expreeion of procollagen Ⅲ in the kidney were significantly inhibited at the same time.Conclusion:Ligustrazin have no effect in decreasing the blood sugar level but have a certain in preventing renal by inhibiting protein expreeion of Procollagen Ⅲ.