Abstract 10247: Establishing a Therapeutically Modifiable ROS/RNS-Beta 1 Adrenergic Receptor Desensitization and Internalization Axis in Aging Coronary Microvessels

Evan Tracy,Michaela N Dukes,Gabrielle Rowe,Jason E. Beare,Amanda J. LeBlanc

Abstract 10247: Establishing a Therapeutically Modifiable ROS/RNS-Beta 1 Adrenergic Receptor Desensitization and Internalization Axis in Aging Coronary Microvessels

2021

Evan Tracy
Michaela N Dukes
Gabrielle Rowe
Jason E. Beare
Amanda J. LeBlanc

Introduction: Coronary Microvascular Disease (CMD) causes hyperconstriction, reduced perfusion, and chronic angina in aging. We previously showed increased coronary microvascular ROS and reduced NO...

Keywords:

Internalization
desensitization
Beta-1 adrenergic receptor
Antioxidant
Stem-cell therapy
Perfusion
Pharmacology
Medicine
Oxidative stress
Adrenergic

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